Mixed-effects Cox models of alcohol dependence in extended families
نویسندگان
چکیده
منابع مشابه
Mixed Effects Cox Models
Like many other projects, this software library started with a data set and a problem. From this came statistical ideas for a solution, followed by some initial programming — which more than anything else helped to define the real computational and statistical issues — and then a more ambitious programming solution. The problem turned out to be harder than I thought; the first release-worthy co...
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BACKGROUND The age at onset of alcohol dependence (AD) is a critical moderator of genetic associations for alcohol dependence. The present study evaluated whether single nucleotide polymorphisms (SNPs) can influence the age at onset of AD in large high-risk families from the Collaborative Study on the Genetics of Alcoholism (COGA). METHODS Genomewide SNP genotyping was performed in 1788 regul...
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Drug addiction has serious health and social consequences. In the last 50 years, a wide range of techniques have been developed to model specific aspects of drug-taking behaviors and have greatly contributed to the understanding of the neurobiological basis of drug abuse and addiction. In the last two decades, new models have been proposed in an attempt to capture the more genuine aspects of ad...
متن کاملFamily-based association analysis of alcohol dependence implicates KIAA0040 on Chromosome 1q in multiplex alcohol dependence families
BACKGROUND A previous genome-wide linkage study of alcohol dependence in multiplex families found a suggestive linkage result for a region on Chromosome 1 near microsatellite markers D1S196 and D1S2878. The KIAA0040 gene has been mapped to this region (1q24 - q25). A recent genome-wide association study using SAGE (the Study of Addiction: Genetics and Environment) and COGA (Collaborative Study ...
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ژورنال
عنوان ژورنال: BMC Genetics
سال: 2005
ISSN: 1471-2156
DOI: 10.1186/1471-2156-6-s1-s127